[The ts phenotype of reisolates from children inoculated with live cold-adapted influenza vaccine type A].
Identifieur interne : 002D75 ( Main/Exploration ); précédent : 002D74; suivant : 002D76[The ts phenotype of reisolates from children inoculated with live cold-adapted influenza vaccine type A].
Auteurs : T E Medvedeva ; Iu R. Romanova ; M I Gushchina ; L G Rudenko ; Iu Z. Gendon ; G I Aleksandrova ; A I KlimovSource :
- Voprosy virusologii [ 0507-4088 ]
Descripteurs français
- KwdFr :
- Antigènes viraux (analyse), Antigènes viraux (génétique), Basse température, Enfant, Enfant d'âge préscolaire, Facteurs temps, Gènes viraux (génétique), Humains, Mutation, Passage en série, Phénotype, Recombinaison génétique (génétique), Température, Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (génétique), Vaccins antigrippaux (immunologie), Virus de la grippe A (génétique), Virus de la grippe A (immunologie), Virus de la grippe A (isolement et purification), Épitopes (analyse), Épitopes (génétique).
- MESH :
- administration et posologie : Vaccins antigrippaux.
- analyse : Antigènes viraux, Épitopes.
- génétique : Antigènes viraux, Gènes viraux, Recombinaison génétique, Vaccins antigrippaux, Virus de la grippe A, Épitopes.
- immunologie : Vaccins antigrippaux, Virus de la grippe A.
- isolement et purification : Virus de la grippe A.
- Basse température, Enfant, Enfant d'âge préscolaire, Facteurs temps, Humains, Mutation, Passage en série, Phénotype, Température.
English descriptors
- KwdEn :
- Antigens, Viral (analysis), Antigens, Viral (genetics), Child, Child, Preschool, Cold Temperature, Epitopes (analysis), Epitopes (genetics), Genes, Viral (genetics), Humans, Influenza A virus (genetics), Influenza A virus (immunology), Influenza A virus (isolation & purification), Influenza Vaccines (administration & dosage), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Mutation, Phenotype, Recombination, Genetic (genetics), Serial Passage, Temperature, Time Factors.
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , analysis : Antigens, Viral, Epitopes.
- chemical , genetics : Antigens, Viral, Epitopes, Influenza Vaccines.
- genetics : Genes, Viral, Influenza A virus, Recombination, Genetic.
- immunology : Influenza A virus, Influenza Vaccines.
- isolation & purification : Influenza A virus.
- Child, Child, Preschool, Cold Temperature, Humans, Mutation, Phenotype, Serial Passage, Temperature, Time Factors.
Abstract
Using mutants of fowl plague virus (FRV) which have single temperature-sensitive (ts) mutations in some genes, an analysis was carried out on reisolates from children of 3-6 years, vaccinated with a monovaccine from recombinant strains of influenza type A virus. The recombinants were obtained by crossing of current epidemic strains of subtypes A (HINI) and a (H3N2) with the cold-adapted (XA) ts-donor of attenuation A/Leningrad/134/47/57 (H2N2) from which they, as a rule, inherited 5 ts-mutations in genes 1 (PB2), 2 (PB1), 5 (NP), 7 (M), and 8 (NS). All the reisolates were shown to retain the ts-phenotype. However, in the recombination test some reisolates (most frequently those isolated at late periods of vaccination infection) no ts-mutations could be found in 1-3 genes coding for proteins of the polymerase complex, less frequently for NP and NS proteins but not for M proteins.
PubMed: 1697128
Affiliations:
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Le document en format XML
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Gendon</name></author><author><name sortKey="Aleksandrova, G I" sort="Aleksandrova, G I" uniqKey="Aleksandrova G" first="G I" last="Aleksandrova">G I Aleksandrova</name></author><author><name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A I" last="Klimov">A I Klimov</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>1990 Mar-Apr</MedlineDate></PubDate></date><idno type="RBID">pubmed:1697128</idno><idno type="pmid">1697128</idno><idno type="wicri:Area/PubMed/Corpus">000456</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000456</idno><idno type="wicri:Area/PubMed/Curation">000456</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000456</idno><idno type="wicri:Area/PubMed/Checkpoint">000626</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000626</idno><idno type="wicri:Area/Ncbi/Merge">000185</idno><idno type="wicri:Area/Ncbi/Curation">000185</idno><idno type="wicri:Area/Ncbi/Checkpoint">000185</idno><idno type="wicri:doubleKey">0507-4088::Medvedeva T:the:ts:phenotype</idno><idno type="wicri:Area/Main/Merge">002F50</idno><idno type="wicri:Area/Main/Curation">002D75</idno><idno type="wicri:Area/Main/Exploration">002D75</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[The ts phenotype of reisolates from children inoculated with live cold-adapted influenza vaccine type A].</title><author><name sortKey="Medvedeva, T E" sort="Medvedeva, T E" uniqKey="Medvedeva T" first="T E" last="Medvedeva">T E Medvedeva</name></author><author><name sortKey="Romanova, Iu R" sort="Romanova, Iu R" uniqKey="Romanova I" first="Iu R" last="Romanova">Iu R. Romanova</name></author><author><name sortKey="Gushchina, M I" sort="Gushchina, M I" uniqKey="Gushchina M" first="M I" last="Gushchina">M I Gushchina</name></author><author><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L G" last="Rudenko">L G Rudenko</name></author><author><name sortKey="Gendon, Iu Z" sort="Gendon, Iu Z" uniqKey="Gendon I" first="Iu Z" last="Gendon">Iu Z. Gendon</name></author><author><name sortKey="Aleksandrova, G I" sort="Aleksandrova, G I" uniqKey="Aleksandrova G" first="G I" last="Aleksandrova">G I Aleksandrova</name></author><author><name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A I" last="Klimov">A I Klimov</name></author></analytic><series><title level="j">Voprosy virusologii</title><idno type="ISSN">0507-4088</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigens, Viral (analysis)</term><term>Antigens, Viral (genetics)</term><term>Child</term><term>Child, Preschool</term><term>Cold Temperature</term><term>Epitopes (analysis)</term><term>Epitopes (genetics)</term><term>Genes, Viral (genetics)</term><term>Humans</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (immunology)</term><term>Influenza A virus (isolation & purification)</term><term>Influenza Vaccines (administration & dosage)</term><term>Influenza Vaccines (genetics)</term><term>Influenza Vaccines (immunology)</term><term>Mutation</term><term>Phenotype</term><term>Recombination, Genetic (genetics)</term><term>Serial Passage</term><term>Temperature</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antigènes viraux (analyse)</term><term>Antigènes viraux (génétique)</term><term>Basse température</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs temps</term><term>Gènes viraux (génétique)</term><term>Humains</term><term>Mutation</term><term>Passage en série</term><term>Phénotype</term><term>Recombinaison génétique (génétique)</term><term>Température</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Vaccins antigrippaux (génétique)</term><term>Vaccins antigrippaux (immunologie)</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (immunologie)</term><term>Virus de la grippe A (isolement et purification)</term><term>Épitopes (analyse)</term><term>Épitopes (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigens, Viral</term><term>Epitopes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Viral</term><term>Epitopes</term><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigènes viraux</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genes, Viral</term><term>Influenza A virus</term><term>Recombination, Genetic</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes viraux</term><term>Gènes viraux</term><term>Recombinaison génétique</term><term>Vaccins antigrippaux</term><term>Virus de la grippe A</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child</term><term>Child, Preschool</term><term>Cold Temperature</term><term>Humans</term><term>Mutation</term><term>Phenotype</term><term>Serial Passage</term><term>Temperature</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Basse température</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs temps</term><term>Humains</term><term>Mutation</term><term>Passage en série</term><term>Phénotype</term><term>Température</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Using mutants of fowl plague virus (FRV) which have single temperature-sensitive (ts) mutations in some genes, an analysis was carried out on reisolates from children of 3-6 years, vaccinated with a monovaccine from recombinant strains of influenza type A virus. The recombinants were obtained by crossing of current epidemic strains of subtypes A (HINI) and a (H3N2) with the cold-adapted (XA) ts-donor of attenuation A/Leningrad/134/47/57 (H2N2) from which they, as a rule, inherited 5 ts-mutations in genes 1 (PB2), 2 (PB1), 5 (NP), 7 (M), and 8 (NS). All the reisolates were shown to retain the ts-phenotype. However, in the recombination test some reisolates (most frequently those isolated at late periods of vaccination infection) no ts-mutations could be found in 1-3 genes coding for proteins of the polymerase complex, less frequently for NP and NS proteins but not for M proteins.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Aleksandrova, G I" sort="Aleksandrova, G I" uniqKey="Aleksandrova G" first="G I" last="Aleksandrova">G I Aleksandrova</name><name sortKey="Gendon, Iu Z" sort="Gendon, Iu Z" uniqKey="Gendon I" first="Iu Z" last="Gendon">Iu Z. Gendon</name><name sortKey="Gushchina, M I" sort="Gushchina, M I" uniqKey="Gushchina M" first="M I" last="Gushchina">M I Gushchina</name><name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A I" last="Klimov">A I Klimov</name><name sortKey="Medvedeva, T E" sort="Medvedeva, T E" uniqKey="Medvedeva T" first="T E" last="Medvedeva">T E Medvedeva</name><name sortKey="Romanova, Iu R" sort="Romanova, Iu R" uniqKey="Romanova I" first="Iu R" last="Romanova">Iu R. Romanova</name><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L G" last="Rudenko">L G Rudenko</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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